The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia.

@article{Lynch2010TheIO,
  title={The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia.},
  author={Anne M Lynch and James M Murphy and Ronald Gibbs and Richard J. Levine and Patricia C. Giclas and Jane E. Salmon and V. Michael Holers},
  journal={BJOG : an international journal of obstetrics and gynaecology},
  year={2010},
  volume={117 4},
  pages={456-62}
}
OBJECTIVE To determine the interrelationships during early pregnancy of complement-activation fragments Bb, C3a and sC5b-9, and angiogenesis-related factors placental growth factor (PiGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and their associations with pre-eclampsia. DESIGN Prospective cohort study. SETTING Denver complement study (June 2005-June 2008). POPULATION A total of 668 pregnant women with singleton gestations, recruited between 10 and 15… CONTINUE READING

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