The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease.

@article{Jin2010TheIB,
  title={The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease.},
  author={Youngnam N. Jin and Gail V W Johnson},
  journal={Journal of bioenergetics and biomembranes},
  year={2010},
  volume={42 3},
  pages={199-205}
}
Huntington disease (HD) is an inherited neurodegenerative disease caused by an abnormal expansion of the CAG repeat region in the huntingtin (Htt) gene. Although the pathogenic mechanisms by which mutant Htt (mHtt) causes HD have not been fully elucidated, it is becoming increasingly apparent that mHtt can impair mitochondrial function directly, as well as… CONTINUE READING