The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines

@article{Goodison2003TheIB,
  title={The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines},
  author={Steve Goodison and Carrie S. Viars and Maren L. Grazzini and Virginia Urquidi},
  journal={BMC Genomics},
  year={2003},
  volume={4},
  pages={39 - 39}
}
BackgroundIn order to facilitate the identification of genes involved in the metastatic phenotype we have previously developed a pair of cell lines from the human breast carcinoma cell line MDA-MB-435, which have diametrically opposite metastatic potential in athymic mice. Differential display analysis of this model previously identified a novel gene, DRIM (down regulated in metastasis), the decreased expression of which correlated with metastatic capability. DRIM encodes a protein comprising… CONTINUE READING

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