The interpretation of current-clamp recordings in the cell-attached patch-clamp configuration.

@article{Mason2005TheIO,
  title={The interpretation of current-clamp recordings in the cell-attached patch-clamp configuration.},
  author={Michael J. Mason and Anna Kornfeld Simpson and Martyn P. Mahaut-Smith and Hugh P. C. Robinson},
  journal={Biophysical journal},
  year={2005},
  volume={88 1},
  pages={739-50}
}
In these experiments we have investigated the feasibility and accuracy of recording steady-state and dynamic changes in transmembrane potential noninvasively across an intact cell-attached patch using the current-clamp mode of a conventional patch-clamp amplifier. Using an equivalent circuit mimicking simultaneous whole-cell voltage-clamp and cell-attached current-clamp recordings we have defined both mathematically and experimentally the relationship between the membrane patch resistance, the… CONTINUE READING
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