The interplay of learning and anxiety in the elevated plus-maze.

@article{File1993TheIO,
  title={The interplay of learning and anxiety in the elevated plus-maze.},
  author={S. E. File},
  journal={Behavioural brain research},
  year={1993},
  volume={58 1-2},
  pages={199-202}
}
  • S. E. File
  • Published 1993 in Behavioural brain research
In naive rats benzodiazepines have clear anxiolytic effects in the elevated plus-maze, but in rats with previous plus-maze experience benzodiazepines are ineffective. This phenomenon does not depend on the drug state on trial 1 or on the inter-trial interval and generalises across mazes of different material; it is dependent on experience of the open arm. The phenomenon of "one-trial tolerance" to the anxiolytic effect of benzodiazepines is not seen in other animal tests; and there is no… CONTINUE READING