The interplay of extracellular matrix and microbiome in urothelial bladder cancer

@article{Alfano2016TheIO,
  title={The interplay of extracellular matrix and microbiome in urothelial bladder cancer},
  author={Massimo Alfano and Filippo Canducci and Manuela Nebuloni and Massimo Clementi and Francesco Montorsi and A Salonia},
  journal={Nature Reviews Urology},
  year={2016},
  volume={13},
  pages={77-90}
}
Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenvironment has been recognized as one of the key determinants of cancer development and is being extensively investigated. Data suggest that both the extracellular matrix and the microbiota represent… CONTINUE READING