The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.

@article{Bosscher2003TheIB,
  title={The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression.},
  author={Karolien De Bosscher and Wim Vanden Berghe and Guy Haegeman},
  journal={Endocrine reviews},
  year={2003},
  volume={24 4},
  pages={488-522}
}
The inflammatory response is a highly regulated physiological process that is critically important for homeostasis. A precise physiological control of inflammation allows a timely reaction to invading pathogens or to other insults without causing overreaction liable to damage the host. The cellular signaling pathways identified as important regulators of inflammation are the signal transduction cascades mediated by the nuclear factor-kappaB and the activator protein-1, which can both be… CONTINUE READING
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