The interplay between inflammation and oxidative stress in carcinogenesis.

  title={The interplay between inflammation and oxidative stress in carcinogenesis.},
  author={Somaira Nowsheen and Khaled Aziz and Thomas B Kryston and Nicholas F Ferguson and Alexandros G. Georgakilas},
  journal={Current molecular medicine},
  volume={12 6},
Emerging data suggest that primary dysfunction in the tumor microenvironment is crucial for carcinogenesis. These recent findings make a compelling case for targeting the milieu for cancer chemoprevention as well as therapy. The stroma is an integral part of its physiology, and functionally, one cannot totally dissociate the tumor surrounding from the tumor cells. A thorough understanding of the tumor and stroma will aid us in developing new treatment targets. In this review, we shed light at… CONTINUE READING

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