The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

@article{Czarny2018TheIB,
  title={The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression},
  author={Piotr Czarny and Paulina Wigner and Piotr Galecki and Tomasz Sliwiński},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2018},
  volume={80},
  pages={309-321}
}
A growing body of evidence suggests that inflammation, mitochondrial dysfunction and oxidant-antioxidant imbalance may play a significant role in the development and progression of depression. Elevated levels of reactive oxygen and nitrogen species - a result of oxidant-antioxidant imbalance - may lead to increased damage of biomolecules, including DNA. This was confirmed in depressed patients in a research study conducted by our team and other scientists. 8-oxoguanine - a marker of oxidative… CONTINUE READING

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