The interplay between autophagy and ROS in tumorigenesis

  title={The interplay between autophagy and ROS in tumorigenesis},
  author={Sameera Kongara and Vassiliki Karantza},
  booktitle={Front. Oncol.},
Reactive oxygen species (ROS) at physiological levels are important cell signaling molecules. However, aberrantly high ROS are intimately associated with disease and commonly observed in cancer. Mitochondria are primary sources of intracellular ROS, and their maintenance is essential to cellular health. Autophagy, an evolutionarily conserved process whereby cytoplasmic components are delivered to lysosomes for degradation, is responsible for mitochondrial turnover and removal of damaged… CONTINUE READING
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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP 3 inflammasome

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  • 2011
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