The interplay between Siglecs and sialylated pathogens.

@article{Chang2014TheIB,
  title={The interplay between Siglecs and sialylated pathogens.},
  author={Yung-Chi Chang and Victor Nizet},
  journal={Glycobiology},
  year={2014},
  volume={24 9},
  pages={818-25}
}
Siglecs are mammalian sialic acid (Sia) recognizing immunoglobulin-like receptors expressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on cell surface glycoconjugates and regulate immunological and inflammatory activities of these cells. A large subset referred to as CD33-related Siglecs are inhibitory receptors… CONTINUE READING