The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo.

Abstract

Defects in primary cilia result in human diseases known as ciliopathies. The retinitis pigmentosa GTPase regulator (RPGR), mutated in the most severe form of the eye disease, is located at the transition zone of the ciliary organelle. The RPGR-interacting partner PDEδ is involved in trafficking of farnesylated ciliary cargo, but the significance of this… (More)
DOI: 10.1038/embor.2013.37

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