The internal quaternary ammonium receptor site of Shaker potassium channels

  title={The internal quaternary ammonium receptor site of Shaker potassium channels},
  author={Kathleen L. Choi and C. Mossman and J. Aub{\'e} and G. Yellen},
  • Kathleen L. Choi, C. Mossman, +1 author G. Yellen
  • Published 1993
  • Chemistry, Medicine
  • Neuron
  • Quaternary ammonium (QA) compounds inhibit K+ conductance by entering and occluding the open pore of voltage-activated K+ channels. We characterized the effects of a series of alkyl-triethylammonium blockers on the Shaker K+ channel and tested them on a series of site-directed mutants of the channel protein in order to define the structural features of the binding sites. We found that mutations in two regions of the channel protein, the pore (P) region and the last transmembrane sequence (S6… CONTINUE READING
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