The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting.

@article{Frigerio2001TheIP,
  title={The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting.},
  author={Lorenzo Frigerio and Nicholas A. Jolliffe and Alessandra Di Cola and D H Felipe and Nadine Paris and James Neuhaus and J. Michael Lord and Aldo Ceriotti and Lynne M. Roberts},
  journal={Plant physiology},
  year={2001},
  volume={126 1},
  pages={167-75}
}
Ricin is a heterodimeric toxin that accumulates in the storage vacuoles of castor bean (Ricinus communis) endosperm. Proricin is synthesized as a single polypeptide precursor comprising the catalytic A chain and the Gal-binding B chain joined by a 12-amino acid linker propeptide. Upon arrival in the vacuole, the linker is removed. Here, we replicate these events in transfected tobacco (Nicotiana tabacum) leaf protoplasts. We show that the internal linker propeptide is responsible for vacuolar… CONTINUE READING
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Cis - elements of protein transport to the plant vacuoles

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