The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.

@article{Feng1998TheIR,
  title={The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: overexpression of the nonsignaling interleukin-13 receptor alpha2.},
  author={Niangen Feng and Serena M. Lugli and Bruno Schnyder and Jean Gauchat and Pierre Graber and E Schlagenhauf and B Schnarr and Mich{\`e}le Wiederkehr-Adam and Albert Duschl and Markus H Heim and Regina A. Lutz and Rosita Moser},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1998},
  volume={78 5},
  pages={591-602}
}
Interleukin (IL)-4 and IL-13 are known to bind to shared heteromultimeric receptor complexes of variable composition. Given the many regulatory effects of IL-4 and IL-13 on synovial cells, we aimed to characterize their IL-4/IL-13 receptor (R). Cultivated synovial fibroblasts expressed transcripts for IL-4Ralpha and IL-13Ralpha1, the human homolog of the recently cloned mouse IL-13R, but not the common gamma-chain of the IL-2R. In particular, IL-13Ralpha2 mRNA, encoding a different IL-13R… CONTINUE READING

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