The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.

@article{Donnelly1999TheIS,
  title={The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes.},
  author={Raymond P Donnelly and Harold L Dickensheets and David S. Finbloom},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={1999},
  volume={19 6},
  pages={
          563-73
        }
}
Interleukin-10 (IL-10) activates a diverse array of functional responses in mononuclear phagocytes. Functional IL-10 receptor (IL-10R) complexes are tetramers consisting of two IL-10R1 polypeptide chains and two IL-10R2 chains. Binding of IL-10 to the extracellular domain of IL-10R1 activates phosphorylation of the receptor-associated Janus tyrosine kinases, JAK1 and Tyk2. These kinases then phosphorylate specific tyrosine residues (Y446 and Y496) on the intracellular domain of the IL-10R1… CONTINUE READING

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