The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.

@article{Timms2004TheI1,
  title={The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.},
  author={Andrew E. Timms and Alison M Crane and Anne-Marie Sims and Heather J. Cordell and Linda A. Bradbury and A. Michele Abbott and M. R. Coyne and Owen Beynon and Ibi Herzberg and Gordon W. Duff and Andrei Calin and Lon R. Cardon and Brian P. Wordsworth and Matthew A Brown},
  journal={American journal of human genetics},
  year={2004},
  volume={75 4},
  pages={587-95}
}
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study… CONTINUE READING

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