The interleukin-1 family: 10 years of discovery.

  title={The interleukin-1 family: 10 years of discovery.},
  author={Charles A Dinarello},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={8 15},
Ten years ago the cloning of two interleukin-1 molecules (IL-1 alpha and IL-1 beta) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL-1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL-1 in the femtomolar range and of its ability to induce a response… CONTINUE READING
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