The interleukin‐1 family: 10 years of discovery 1

  title={The interleukin‐1 family: 10 years of discovery 1},
  author={Charles A. Dinarello},
  journal={The FASEB Journal},
  pages={1314 - 1325}
  • C. Dinarello
  • Published 1 December 1994
  • Biology
  • The FASEB Journal
Ten years ago the cloning of two interleukin‐1 molecules (IL‐1α and IL‐1β) resolved the question of whether a single polypeptide could evoke a wide variety of biological effects. During the past decade, the biology of IL‐1 has greatly expanded our understanding of how the host responds to external challenges, such as injury and infection, as well as its role in several diseases. We learned of the remarkable potency of IL‐1 in the femtomolar range and of its ability to induce a response by… 
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Interleukin-1 and interleukin-1 antagonism.
The recent cloning of a naturally occurring IL-1 receptor antagonist (IL-1ra) has opened new experimental and clinical approaches and reduced the severity of diseases such as hemodynamic shock, lethal sepsis, inflammatory bowel disease, experimental arthritis, and the spontaneous proliferation of human leukemic cells.
Interleukin-1 receptor antagonist.
  • W. Arend
  • Biology, Medicine
    Advances in immunology
  • 1993
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It is shown that IL‐1 beta is actively secreted by activated human monocytes via a pathway of secretion different from the classical endoplasmic reticulum‐‐Golgi route, which may involve translocation of intracellular membranes and is increased by stress conditions.
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
The cloning, sequence analysis and expression of murine IL-1 cDNA in Escherichia coli reveals a polypeptide precursor of 270 amino acids that may play a major role in the initiation and amplification of immune and inflammatory responses through its action on these diverse cell populations.
Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4.
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cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.
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