The interferon system: an overview.

@article{DeAndrea2002TheIS,
  title={The interferon system: an overview.},
  author={Marco De Andrea and Raffaella Ravera and Daniela Gioia and Marisa Gariglio and Santo Landolfo},
  journal={European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society},
  year={2002},
  volume={6 Suppl A},
  pages={
          A41-6; discussion A55-8
        }
}
  • M. De Andrea, R. Ravera, +2 authors S. Landolfo
  • Published 1 May 2002
  • Biology, Medicine
  • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Interferons are a family of related and naturally occurring signal proteins grouped in three major species (alpha, beta and gamma) according to their cellular origin and inducing agents and historically described for their antiviral activity. Upon binding to specific receptors they lead to the activation of a signal transduction pathway that activates a broad range of genes, that are now known involved not only in antiviral but also in immunomodulatory and antiproliferative activities. The… Expand
Stimulator of Interferon Genes (STING): A Factor to Consider in Cellular Homeostasis
TLDR
This review aims to briefly describe the stimulator of the interferon genes (a 379-amino acid protein), how it elicits its cellular homeostatic functions with the sole purpose of enhancing cell survival and reducing morbidities. Expand
Interferon Beta: From Molecular Level to Therapeutic Effects.
TLDR
This chapter reviews the current knowledge on IFNβ from its structure, dynamic conformation, signaling pathway, and mechanism of action to its therapeutic effects and discusses immunogenicity and its relation to structural properties. Expand
Evolutionary Pattern of Interferon Alpha Genes in Bovidae and Genetic Diversity of IFNAA in the Bovine Genome
TLDR
The genetic diversity of the bovine interferon alpha A (IFNAA) could be a very good indication of the genetic variation among the different genes of IFNA and could be an adaptation for these species in response to viral challenges they face. Expand
Interferon regulatory factor 1 inactivation in human cancer
TLDR
This review focusses on current knowledge of the roles of IRf-1 and IRF-2 in human cancer, with particular attention paid to the impact ofIRF-1 inactivation. Expand
Interferons: role in cancer therapy.
TLDR
Although IFN signaling is involved in induction of antitumor responses, chronic stimulation of theIFN signaling pathway can induce resistance to various antineoplasm therapies, and understanding this mechanism of action might be a key target of combination therapies. Expand
Cytokines and Interferons: Types and Functions
TLDR
This chapter aims to describe and review the main important cytokines types (notably interferons), including their biological activities, functions and structures, and the relationships between those cytokines with some autoimmune diseases that are promoted by them. Expand
HISTORY OF INTERFERON TREATMENTS IN MULTIPLE SCLEROSIS – 60 YEARS OF PROGRESS
Interferons are biopharmaceutical agents which were discovered based on the phenomenon of viral interference, in 1957. Three categories of interferons were described: IFN I (IFN-α, IFN-β), IFN IIExpand
Human consensus interferons: Bridging the natural and artificial cytokines with intrinsic disorder.
TLDR
If the peculiarities of disorder distribution within the protein sequence are related to protein functionality, then comparison of the disorder profiles of artificial cIFNs (query profiles) with the averaged disorder predisposition profile of human IFNs-α (target profile) can be used in the design of novel cifNs. Expand
Interferon Regulatory Factor 3 (IRF3) Characterisation in Four Mammalian Species Using Bioinformatics Method
TLDR
The information obtained in this study could serve as a guide when using the IRF3 gene as a marker to select animals for disease resistance because of the critical role they play in antiviral defense. Expand
Molecular structure and immune-stimulated transcriptional modulation of the first teleostean IFP35 counterpart from rockfish (Sebastes schlegelii).
TLDR
The expression of RfIFP35 during immune challenge with poly I:C and lipopolysaccharide treatments affirms its putative importance in the first-line host defense system and the modulation patterns of both Rf IFP35 and R fIFN-γ suggest that RfifP35 may be induced by RfIFE-γ. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Mechanisms of viral inhibition by interferons.
TLDR
This review will attempt to evaluate evidence of the involvement of the IFN-inducible proteins in the expression of the antiviral state against RNA or DNA viruses. Expand
The Ifi 200 genes: an emerging family of IFN-inducible genes.
TLDR
The data available demonstrate that at least two members of the Ifi 200 protein family, p202 and p204, inhibit cell proliferation in vitro and high constitutive levels of p204 expression impair normal embryo development in transgenic animals. Expand
The interferon system and interferon regulatory factor transcription factors -- studies from gene knockout mice.
TLDR
This review summarizes the current knowledge of the functions of IRF family members revealed by the gene targeting study in mice, focusing on the regulation of the IFN system. Expand
Interferons and other regulatory cytokines
From an Antiviral Factor to a Family of Multifunctional Cytokines The Interferon Gene Family Induction of IFN-+ga+n and IFN-+gb+n Interferon Receptors Interferons as Multifunctional Gene ActivatorsExpand
IRF family of transcription factors as regulators of host defense.
TLDR
Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis. Expand
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.
TLDR
This review will examine how two receptor associated tyrosine kinases from the JAK family mediate the transduction of signal directly from receptor to nucleus. Expand
The double-stranded RNA-dependent protein kinase PKR: structure and function.
  • M. Clemens, A. Elia
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 1997
TLDR
The possibility that PKR may function as a tumor suppressor and inducer of apoptosis suggests that this IFN-regulated protein kinase may be of central importance to the control of cell proliferation and transformation. Expand
Interferon-γ–inducible protein p16. a new target of antinuclear antibodies in patients with systemic lupus erythematosus
TLDR
Anti-p16 represents a main ANA specificity and may help to elucidate IFN gamma-dependent nuclear processes and to link autoantibody production to states ofIFN gamma activation. Expand
Interferon-gamma-inducible protein p16. A new target of antinuclear antibodies in patients with systemic lupus erythematosus.
TLDR
Anti-p16 represents a main ANA specificity and may help to elucidate IFN gamma-dependent nuclear processes and to link autoantibody production to states ofIFN gamma activation. Expand
2-5A-Dependent RNase L: A Regulated Endoribonuclease in the Interferon System
TLDR
This chapter discusses perspectives on the 2-5A system, and elaborates structure and functions of RNase L, and explains distribution, localization, and regulation ofRNase L and its gene. Expand
...
1
2
3
...