The interferon stimulated gene 54 promotes apoptosis.

  title={The interferon stimulated gene 54 promotes apoptosis.},
  author={Marcin Stawowczyk and Sarah Van Scoy and Kanagarajan Prasanna Kumar and Nancy C. Reich},
  journal={The Journal of biological chemistry},
  volume={286 9},
The ability of interferons (IFNs) to inhibit viral replication and cellular proliferation is well established, but the specific contribution of each IFN-stimulated gene (ISG) to these biological responses remains to be completely understood. In this report we demonstrate that ISG54, also known as IFN-induced protein with tetratricopeptide repeats 2 (IFIT2), is a mediator of apoptosis. Expression of ISG54, independent of IFN stimulation, elicits apoptotic cell death. Cell death and apoptosis… CONTINUE READING