The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.

@article{Wang2007TheIP,
  title={The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.},
  author={X. Wang and E. Hinson and P. Cresswell},
  journal={Cell host & microbe},
  year={2007},
  volume={2 2},
  pages={
          96-105
        }
}
  • X. Wang, E. Hinson, P. Cresswell
  • Published 2007
  • Biology, Medicine
  • Cell host & microbe
  • Interferons initiate the host antiviral response by inducing a number of genes, most with no defined antiviral function. Here we show that the interferon-induced protein viperin inhibits influenza A virus release from the plasma membrane of infected cells. Viperin expression altered plasma membrane fluidity by affecting the formation of lipid rafts, which are detergent-resistant membrane microdomains known to be the sites of influenza virus budding. Intracellular interaction of viperin with… CONTINUE READING
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