The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.

@article{Liu2005TheIP,
  title={The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation.},
  author={Chuan-ju Liu and Eric Chang and Jin Yu and Cathy S Carlson and Lisa Prazak and Xiu-ping Yu and Bo Ding and Peter Lengyel and Paul E. Di Cesare},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 4},
  pages={2788-96}
}
The differentiation of uncommitted mesenchymal cells into osteoblasts is a fundamental molecular event governing both embryonic development and bone repair. The bone morphogenetic proteins (BMPs) are important regulators of this process; they function by binding to cell surface receptors and signaling by means of Smad proteins. Core binding factor alpha-1 (Cbfa1), a member of the runt family of transcription factors, is an essential transcriptional regulator of osteoblast differentiation and… CONTINUE READING

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