The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc.

@article{Weihua1997TheIM,
  title={The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc.},
  author={Xu Weihua and Daniel J. Lindner and Dhananjaya V. Kalvakolanu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 14},
  pages={7227-32}
}
p48 protein is an integral component of the multimeric interferon (IFN)-regulated transcription factor, ISGF3. We have shown earlier that this gene is regulated by a novel IFN-gamma-regulated element. In addition to the IFN-regulated element, a myc-max binding site is also present in this promoter. In this investigation we have studied the role of this site in the regulation of the p48 gene. In serum-induced quiescent cells Myc up-regulated the expression of p48 mRNA. We show that the… CONTINUE READING
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