The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.

@article{Balasubramanian2011TheIG,
  title={The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.},
  author={Sujata Balasubramanian and Meiyun Fan and Angela F. Messmer-Blust and Chuan He Yang and Jill A. Trendel and Jonathan A. Jeyaratnam and Lawrence M Pfeffer and Deborah J. Vestal},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={20054-64}
}
Matrix metalloproteinase-9 (MMP-9) is important in numerous normal and pathological processes, including the angiogenic switch during tumor development and tumor metastasis. Whereas TNF-α and other cytokines up-regulate MMP-9 expression, interferons (IFNs) inhibit MMP-9 expression. We found that IFN-γ treatment or forced expression of the IFN-induced GTPase, mGBP-2, inhibit TNF-α-induced MMP-9 expression in NIH 3T3 fibroblasts, by inhibiting MMP-9 transcription. The NF-κB transcription factor… CONTINUE READING
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