The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation.

@article{Saberwal2009TheIC,
  title={The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation.},
  author={Gurveen Saberwal and Elizabeth A. Horvath and Liangqing Hu and Chunliu Zhu and Elizabeth E. Hjort and Elizabeth A. Eklund},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 48},
  pages={33242-54}
}
The interferon consensus sequence binding protein (ICSBP) is an interferon regulatory transcription factor with leukemia-suppressor activity. ICSBP regulates genes that are involved in phagocyte function, proliferation, and apoptosis. In murine models ICSBP deficiency results in a myeloproliferative disorder (MPD) with increased mature neutrophils. Over time this MPD progresses to acute myeloid leukemia (AML), suggesting that ICSBP deficiency is adequate for MPD, but additional genetic lesions… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-2 of 2 references

NUMBER 48 JOURNAL OF BIOLOGICAL CHEMISTRY 33253 by gest on M arch 7, 2015 hp://w w w .jb.org/ D ow nladed from Chem

W. Huang, C. Zhu, H. Wang, E. Horvath, E. A. Eklund
J. Biol. ICSBP Activates FANCF Transcription NOVEMBER • 2008

ICSBP Activates FANCF Transcription 33254 JOURNAL OF BIOLOGICAL CHEMISTRY

G. G. Loots, I. Ovcharenko, L. Pachter, I. Dubchak, E. M. Rubin
Genome Res • 2002

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