The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity.

@article{Hale1992TheIO,
  title={The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity.},
  author={V. G. Hale and Leslie Z. Benet},
  journal={Pharmacology},
  year={1992},
  volume={44 5},
  pages={
          273-82
        }
}
The interconversion and elimination of prednisone (PO) and prednisolone (POH) were examined in human and rabbit liver, kidney, lung and skeletal muscle preparations to determine the effect of organ disruption on in vitro metabolism within multiple organs of two species. Results from microsomes, homogenates and minces were compared to determine the effect of various stages of tissue disruption on the reversible and irreversible metabolism of the glucocorticoids. Oxidation of POH to PO was… 
4 Citations
Pharmacokinetic and Pharmacoimmunodynamic Interactions Between Prednisolone and Sirolimus in Adrenalectomized Rats
TLDR
The adrenalectomized rat may be a suitable animal model to characterize drug effects on lymphocyte trafficking and reactivity and their joint therapeutic use is promising.
Pharmacokinetics of reversible metabolic systems