The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

@inproceedings{Comstra2017TheIO,
  title={The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors},
  author={Heather Skye Comstra and Jacob McArthy and Samantha Rudin-Rush and Cortnie Hartwig and Avanti Gokhale and Stephanie A Zlatic and Jessica Bailey Blackburn and Erica M Werner and Michael J. Petris and Priya Esilda D'Souza and Parinya Panuwet and Dana Boyd Barr and Vladimir V Lupashin and Alysia D Vrailas-Mortimer and Victor Faundez},
  booktitle={eLife},
  year={2017}
}
Genetic and environmental factors, such as metals, interact to determine neurological traits. We reasoned that interactomes of molecules handling metals in neurons should include novel metal homeostasis pathways. We focused on copper and its transporter ATP7A because ATP7A null mutations cause neurodegeneration. We performed ATP7A immunoaffinity chromatography and identified 541 proteins co-isolating with ATP7A. The ATP7A interactome concentrated gene products implicated in neurodegeneration… CONTINUE READING
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