The interactions of ethanol with the benzodiazepine-GABA receptor-ionophore complex.

@article{Ticku1983TheIO,
  title={The interactions of ethanol with the benzodiazepine-GABA receptor-ionophore complex.},
  author={Maharaj K. Ticku and T P Burch and William C. Davis},
  journal={Pharmacology, biochemistry, and behavior},
  year={1983},
  volume={18 Suppl 1},
  pages={15-8}
}
Ethanol, barbiturates and benzodiazepines have similar pharmacological effects. All of these drugs facilitate the inhibitory transmission mediated by GABA. Drugs that facilitate GABAergic transmission are effective in alleviating ethanol withdrawal symptoms. Acute ethanol administration increases the number of low affinity GABA receptor sites, while, during ethanol withdrawal, the affinity of this site is decreased. This decreased affinity during withdrawal correlated with the audiogenic… CONTINUE READING
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