The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase.

@article{Petzer2014TheIO,
  title={The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase.},
  author={An{\'e}l Petzer and Brian Herbert Harvey and Jacobus P Petzer},
  journal={Toxicology and applied pharmacology},
  year={2014},
  volume={274 3},
  pages={488-93}
}
Methylene blue (MB) is reported to possess diverse pharmacological actions and is attracting increasing attention for the treatment of neurodegenerative disorders such as Alzheimer's disease. Among the pharmacological actions of MB, is the significant inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). These activities may, at least in part, underlie MB's beneficial effects in Alzheimer's disease. MB is metabolized to yield N-demethylated products of which azure B, the… CONTINUE READING

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