The interactions between indomethacin and cytotoxic drugs in mice bearing B-16 melanomas.

@article{Hofer1980TheIB,
  title={The interactions between indomethacin and cytotoxic drugs in mice bearing B-16 melanomas.},
  author={Dominik Hofer and A M Dubitsky and P Re{\"i}lly and Maria Gabriella Santoro and Bernard M. Jaffe},
  journal={Prostaglandins},
  year={1980},
  volume={20 6},
  pages={1033-8}
}
We have compared the effects of indomethacin alone (100 microgram/mouse/day) with those of indomethacin plus adriamycin, 5-FU, nitrogen mustard, thioTEPA, and vincristine on B-16 tumor cell proliferation in vivo. As we have previously described, after four days of treatment with indomethacin, subcutaneous tumors were slightly smaller and lighter in weight, but contained more melanoma cells. Addition of indomethacin to cytotoxic regimens resulted in either no change or a decrease in the… CONTINUE READING