The interaction of platelet factor four and glycosaminoglycans.

  title={The interaction of platelet factor four and glycosaminoglycans.},
  author={Joseph Loscalzo and B Melnick and Robert I. Handin},
  journal={Archives of biochemistry and biophysics},
  volume={240 1},
The interaction of platelet factor four (PF-4) with glycosaminoglycans (GAG) was evaluated using fluorescence spectroscopy, a radioligand binding assay, and a functional assay utilizing antithrombin III and factor Xa. In these studies, we have (i) characterized the binding parameters for PF-4 to several forms of heparin and to dextran sulfate; (ii) examined the structural features of these glycosaminoglycans which support PF-4 binding; and (iii) examined the effects of selective digestion of… CONTINUE READING
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