The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion.

Abstract

This investigation was designed to determine whether nano-sized manganese oxide (Mn-40 nm) particles would induce dopamine (DA) depletion in a cultured neuronal phenotype, PC-12 cells, similar to free ionic manganese (Mn(2+)). Cells were exposed to Mn-40 nm, Mn(2+) (acetate), or known cytotoxic silver nanoparticles (Ag-15 nm) for 24 h. Phase-contrast… (More)

Topics

Cite this paper

@article{Hussain2006TheIO, title={The interaction of manganese nanoparticles with PC-12 cells induces dopamine depletion.}, author={Saber M. Hussain and Amanda K Javorina and Amanda M. Schrand and Helen Duhart and Syed F. Ali and John J. Schlager}, journal={Toxicological sciences : an official journal of the Society of Toxicology}, year={2006}, volume={92 2}, pages={456-63} }