The interaction of local anesthetics with the ryanodine receptor of the sarcoplasmic reticulum

@article{ShoshanBarmatz2004TheIO,
  title={The interaction of local anesthetics with the ryanodine receptor of the sarcoplasmic reticulum},
  author={Varda Shoshan-Barmatz and Sigalit Zchut},
  journal={The Journal of Membrane Biology},
  year={2004},
  volume={133},
  pages={171-181}
}
SummaryThe effects of various local anesthetics (LAs) on the skeletal muscle ryanodine receptor were tested. The LAs were divided into three categories according to their effects on the binding of ryanodine to the junctional sarcoplasmic reticulum membranes. Ryanodine binding was assayed in the presence of 0.2 m NaCl and 10 μm CaCl2. Tetracaine and dibucaine inhibit the binding with half-maximal inhibition (CI50) of 0.12 and 0.25 mm, respectively, while inhibition by benzocaine and procaine… 
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