The interaction of human dendritic cells with yeast and germ-tube forms of Candida albicans leads to efficient fungal processing, dendritic cell maturation, and acquisition of a Th1 response-promoting function.

@article{Romagnoli2004TheIO,
  title={The interaction of human dendritic cells with yeast and germ-tube forms of Candida albicans leads to efficient fungal processing, dendritic cell maturation, and acquisition of a Th1 response-promoting function.},
  author={Giulia Romagnoli and Roberto Nisini and Paola Chiani and Sabrina Mariotti and Raffaela Teloni and Antonio Cassone and Antonella Torosantucci},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={75 1},
  pages={117-26}
}
T helper cell type 1 (Th1) cell-mediated immunity plays a critical role in protection against the opportunistic pathogen Candida albicans. Virulence of the fungus is closely associated with its ability to form germ-tubes (GT), the early phase of the dimorphic transition from the commensal yeast (Y) to the more invasive hyphal (H) form. In this study, we examined the functional outcome of the interaction of Y or GT forms with human dendritic cells (DCs), professional antigen-presenting cells… CONTINUE READING

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