The interaction of heparin sulfate and adeno-associated virus 2.

@article{Qiu2000TheIO,
  title={The interaction of heparin sulfate and adeno-associated virus 2.},
  author={Jin Qiu and Akiyoshi Handa and Martha Kirby and Kevin E. Brown},
  journal={Virology},
  year={2000},
  volume={269 1},
  pages={137-47}
}
Recently heparan sulfate was proposed as the host cell receptor for the dependovirus, adeno-associated virus type 2 (AAV2). We show that although heparan sulfate on the cell surface may contribute to the binding of AAV2 to permissive cells, the amount of heparan sulfate on the cell surface as determined by flow cytometry using four different monoclonal antibodies does not correlate with AAV2 binding to cells or recombinant AAV2 transduction efficiency. Experiments with either mutant CHO cells… CONTINUE READING

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