The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse

@article{Jacobsen2014TheIO,
  title={The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse},
  author={Jacob P. R. Jacobsen and Per Plenge and Benjamin D. Sachs and Alan L Pehrson and Manuel Cajina and Yunzhi Du and Wendy Roberts and Meghan L. Rudder and Prachiti Dalvi and Taylor J. Robinson and Sharon P. O’Neill and King S. Khoo and Connie Sanchez Morillo and Xiaodong Zhang and Marc G. Caron},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={4527-4540}
}
Escitalopram appears to be a superior antidepressant to racemic citalopram. It has been hypothesized that binding of R-citalopram to the serotonin transporter (SERT) antagonizes escitalopram binding to and inhibition of the SERT, thereby curtailing the elevation of extracellular 5-hydroxytryptamine (5-HTExt), and hence antidepressant efficacy. Further, it has been suggested that a putative allosteric binding site is important for binding of escitalopram to the primary, orthosteric, site, and… CONTINUE READING
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The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram

C Sanchez
Basic Clin Pharmacol Toxicol • 2006
View 10 Excerpts
Highly Influenced

Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: in-vitro and in-vivo studies.

The international journal of neuropsychopharmacology • 2007
View 9 Excerpts
Highly Influenced

The clinical pharmacokinetics of escitalopram.

Clinical pharmacokinetics • 2007
View 2 Excerpts
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