The interaction of ellipticine derivatives with nucleic acids studied by optical and 1H‐nmr spectroscopy: Effect of size of the heterocyclic ring system

@article{Behravan1994TheIO,
  title={The interaction of ellipticine derivatives with nucleic acids studied by optical and 1H‐nmr spectroscopy: Effect of size of the heterocyclic ring system},
  author={G. Behravan and M. Leijon and U. Sehlstedt and B. Nord{\'e}n and H. Vallberg and J. Bergman and A. Gr{\"a}uslund},
  journal={Biopolymers},
  year={1994},
  volume={34}
}
  • G. Behravan, M. Leijon, +4 authors A. Gräuslund
  • Published 1994
  • Chemistry, Medicine
  • Biopolymers
  • The DNA interaction of derivatives of ellipticine with heterocyclic ring systems with three, four, or five rings and a dimethylaminoethyl side chain was studied. Optical spectroscopy of drug complexes with calf thymus DNA, poly [(dA‐dT) · (dA‐dT)], or poly [(dG‐dC) · (dG‐dC)] showed a 10 nm bathochromic shift of the light absorption bands of the pentacyclic and tetracyclic compounds upon binding to the nucleic acids, which indicates binding by intercalation. For the tricyclic compound a smaller… CONTINUE READING
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