The interaction of cytosolic epoxide hydrolase with chiral epoxides.

@article{Dietze1993TheIO,
  title={The interaction of cytosolic epoxide hydrolase with chiral epoxides.},
  author={E. C. Dietze and E. Kuwano and B. Hammock},
  journal={The International journal of biochemistry},
  year={1993},
  volume={25 1},
  pages={
          43-52
        }
}
  • E. C. Dietze, E. Kuwano, B. Hammock
  • Published 1993
  • Chemistry, Medicine
  • The International journal of biochemistry
  • 1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-phenylpropyl carbonate had a KM of 33 and 68 microns and a Vmax of 16 and 27 mumol/min/mg, respectively. With the (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-(4-nitrophenyl)propyl carbonate, cytosolic epoxide hydrolase had a KM of 8.0 and 15 microM and a Vmax of 7.8 and 5.0 mumol… CONTINUE READING
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