The interaction of cytosolic epoxide hydrolase with chiral epoxides.

  title={The interaction of cytosolic epoxide hydrolase with chiral epoxides.},
  author={E. C. Dietze and E. Kuwano and B. Hammock},
  journal={The International journal of biochemistry},
  volume={25 1},
  • E. C. Dietze, E. Kuwano, B. Hammock
  • Published 1993
  • Chemistry, Medicine
  • The International journal of biochemistry
  • 1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-phenylpropyl carbonate had a KM of 33 and 68 microns and a Vmax of 16 and 27 mumol/min/mg, respectively. With the (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-(4-nitrophenyl)propyl carbonate, cytosolic epoxide hydrolase had a KM of 8.0 and 15 microM and a Vmax of 7.8 and 5.0 mumol… CONTINUE READING
    6 Citations
    Soluble Epoxide Hydrolase: Sex Differences and Role in Endothelial Cell Survival
    • 30


    Inhibition of cytosolic epoxide hydrolase by trans-3-phenylglycidols.
    • 44
    Continuous spectrophotometric assays for cytosolic epoxide hydrolase.
    • 24
    Human liver cytosolic epoxide hydrolases.
    • 20
    Antimutagenesis by shift in monooxygenase isoenzymes and induction of epoxide hydrolase.
    • F. Oesch
    • Chemistry, Medicine
    • Mutation research
    • 1988
    • 16