The interaction of chalcones with tubulin.

@article{Lawrence2000TheIO,
  title={The interaction of chalcones with tubulin.},
  author={Nicholas Lawrence and Alan T. McGown and Sylvie Ducki and John A. Hadfield},
  journal={Anti-cancer drug design},
  year={2000},
  volume={15 2},
  pages={135-41}
}
The chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prepared and assessed for their ability to inhibit cell growth in vitro. The cytotoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assembly. Some of the chalcones were shown to bind to the type II oestrogen receptor.