The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol.

@article{Fernndez1983TheIO,
  title={The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol.},
  author={M. Fern{\'a}ndez and G. Carter and T. Palmer},
  journal={British journal of clinical pharmacology},
  year={1983},
  volume={15 1},
  pages={
          95-101
        }
}
1 Canrenone, the major active metabolite of spironolactone, decreased [3H]-progesterone binding to isolated uterine cytosolic progesterone receptors. The inhibition was concentration-dependent. 2 Canrenone did not alter [3H]-oestradiol binding to isolated uterine cytosolic oestrogen receptors. 3 Canrenone inhibition of progesterone binding to isolated cytosolic receptors was strictly competitive: Kd (apparent dissociation constant for progesterone binding) was increased in a concentration… Expand
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