The interaction of bioactive peptides with an immobilized phosphatidylcholine monolayer.

@article{Mozsolits1999TheIO,
  title={The interaction of bioactive peptides with an immobilized phosphatidylcholine monolayer.},
  author={Henriette Mozsolits and Tae Ho Lee and Hugh Wirth and Patrick Perlmutter and Marie Isabel Aguilar},
  journal={Biophysical journal},
  year={1999},
  volume={77 3},
  pages={1428-44}
}
The interaction of three bioactive peptides, bombesin, beta-endorphin, and glucagon with a phosphatidylcholine monolayer that was immobilized to porous silica particles and packed into a stainless steel column cartridge, has been studied using dynamic elution techniques. This immobilized lipid monolayer provides a biophysical model system with which to study the binding of peptides to a lipid membrane. In particular, the influence of temperature and methanol concentration on the affinity of… CONTINUE READING