The interaction of beta-N-methylamino-L-alanine with bicarbonate: an 1H-NMR study.

@article{Nunn1989TheIO,
  title={The interaction of beta-N-methylamino-L-alanine with bicarbonate: an 1H-NMR study.},
  author={P. B. Nunn and Peter O'Brien},
  journal={FEBS letters},
  year={1989},
  volume={251 1-2},
  pages={31-5}
}
The mode of action of the neurotoxic, non-protein amino acid beta-N-methylamino-L-alanine (L-BMAA) is unknown. We have shown, using 1H-NMR spectroscopy, that L-BMAA forms a stable adduct with bicarbonate (probably a carbamate). The properties of this adduct may explain the observation that L-BMAA and N-methyl-D-aspartic acid appear to act at the same central nervous system receptors.