The interaction of antidepressant drugs with enteric 5-HT7 receptors

  title={The interaction of antidepressant drugs with enteric 5-HT7 receptors},
  author={Adele Lucchelli and Maria Grazia Santagostino-Barbone and G D'agostino and Elisabetta Masoero and Marcello Tonini},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Abstract. In this study the functional interaction of the antidepressant drugs amitriptyline, mianserin, maprotiline, imipramine, fluoxetine and the putative antidepressant drug flibanserin has been studied on 5-HT7-mediated responses to 5-carboxamidotryptamine (5-CT) in the guinea-pig ileum.5-CT induced a concentration-dependent inhibition of the contractile response to substance P (100 nM). Except for fluoxetine and flibanserin, all the antidepressants antagonized by different degrees the 5… 

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