The interaction of alpha 1-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness.

@article{Forteza1996TheIO,
  title={The interaction of alpha 1-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness.},
  author={Rosanna Malbr{\'a}n Forteza and Yelena Botvinnikova and Ashfaq Ahmed and Amparo Cort{\'e}s and Robert H. Gundel and Adam Wanner and William M. Abraham},
  journal={American journal of respiratory and critical care medicine},
  year={1996},
  volume={154 1},
  pages={36-42}
}
We reported previously that the development of airway hyperresponsiveness (AHR) 24 h after antigen challenge in allergic sheep was associated with increased tissue kallikrein activity (TK) and decreased alpha-1-proteinase inhibitor (alpha 1-PI) activity in bronchoalveolar fluid (BAL). The inverse correlation between TK and alpha 1-PI in these experiments suggested that administration of alpha 1-PI might reduce TK activity and block AHR. To test this hypothesis, airway responsiveness, as… CONTINUE READING

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