The interaction of SRC kinase with beta3 integrin tails: a potential therapeutic target in thrombosis and cancer.


Activation of Src family kinases is an important event downstream of integrin adhesion signaling in many cell types. A particularly intriguing connection between an integrin and a Src family kinase was first discovered in platelets, where the selective direct interaction of alphaIIbbeta3 integrins with c-Src promotes full kinase activation of c-Src through… (More)
DOI: 10.1100/tsw.2010.114