The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria.

@article{Esposti1996TheIO,
  title={The interaction of Q analogs, particularly hydroxydecyl benzoquinone (idebenone), with the respiratory complexes of heart mitochondria.},
  author={Mauro Degli Esposti and Anna Ngo and Anna Ghelli and Bruna Benelli and Vincenzo Carelli and H. Mclennan and A. W. Linnane},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={330 2},
  pages={395-400}
}
We have studied the interaction of idebenone (2,3-dimethoxy-5-methy-6-(10-hydroxy)decyl-1,4-benzoquinone) with the energy-conserving complexes of the respiratory chain in beef heart mitochondria and compared its energetic efficiency with that of other analogs of coenzyme Q. Idebenone is a very effective substrate for succinate:Q reductase and ubiquinol:cytochrome c reductase, but it is clearly a poor substrate for NADH:Q reductase (complex I). Indeed, idebenone is a strong inhibitor of both the… CONTINUE READING

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