The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.

@article{Albor2006TheIO,
  title={The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.},
  author={Aldo Arturo Res{\'e}ndiz Albor and Sally El-Hizawi and Elizabeth J. Horn and Melanie B. Laederich and Patrick Frosk and K. Wrogemann and Molly Kulesz-Martin},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 35},
  pages={
          25850-66
        }
}
Protein inhibitors of activated STATs (PIAS) family members are ubiquitin-protein isopeptide ligase-small ubiquitin-like modifier ligases for diverse transcription factors. However, the regulation of PIAS protein activity in cells is poorly understood. Previously, we reported that expression of Trim32, a RING domain ubiquitin-protein isopeptide ligase-ubiquitin ligase mutated in human limb-girdle muscular dystrophy type 2H (LGMD2H) and Bardet-Biedl syndrome, is elevated during mouse skin… CONTINUE READING
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