The interaction of PRC2 with RNA or chromatin is mutually antagonistic.

@article{Beltrn2016TheIO,
  title={The interaction of PRC2 with RNA or chromatin is mutually antagonistic.},
  author={Manuel Sanrom{\`a} i Beltr{\'a}n and Christopher M. Yates and Lenka Skalska and Marcus Dewayne Dawson and Filipa Pereira Reis and Keijo Viiri and Cynthia L Fisher and Christopher R. Sibley and Benjamin M. Foster and Till Bartke and Jernej Ule and Richard G Jenner},
  journal={Genome research},
  year={2016},
  volume={26 7},
  pages={
          896-907
        }
}
Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain genes in a repressed state during development. PRC2 is primarily associated with CpG islands at repressed genes and also possesses RNA binding activity. However, the RNAs that bind PRC2 in cells, the subunits that mediate these interactions, and the role of RNA in PRC2 recruitment to chromatin all remain unclear. By performing iCLIP for PRC2 in comparison with other RNA binding proteins, we show here that PRC2 binds nascent RNA… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Noncoding RNA and Polycomb recruitment.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Promiscuous RNA binding by Polycomb Repressive Complex 2

  • Nature Structural &Molecular Biology
  • 2013
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL