The interaction of HMGB1 and linker histones occurs through their acidic and basic tails.

@article{Cato2008TheIO,
  title={The interaction of HMGB1 and linker histones occurs through their acidic and basic tails.},
  author={Laura Cato and Katherine Stott and Matthew A Watson and Jean O. Thomas},
  journal={Journal of molecular biology},
  year={2008},
  volume={384 5},
  pages={1262-72}
}
H1 and HMGB1 bind to linker DNA in chromatin, in the vicinity of the nucleosome dyad. They appear to have opposing effects on the nucleosome, H1 stabilising it by "sealing" two turns of DNA around the octamer, and HMGB1 destabilising it, probably by bending the adjacent DNA. Their presence in chromatin might be mutually exclusive. Displacement/replacement of one by the other as a result of their highly dynamic binding in vivo might, in principle, involve interactions between them. Chemical… CONTINUE READING

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